                         SEQUENCE LISTING

<110>  Schering Corporation
 
<120>  Panel of Biomarkers for Prediction of FTI Efficacy

<130>  JB06457

<160>  48    

<170>  PatentIn version 3.3

<210>  1
<211>  3925
<212>  DNA
<213>  Homo sapiens

<400>  1
agcggggctg cgcgaagtca tcgctgttcc agacagcgat gactcgagag cggtgggggt     60

ggcggcgcga tcggccgggc tgtaaccgtc gtctgtccgg gagcggctgg agcggcagcg    120

gcggccgggc acggcgcgag gtgacgccac agggcagcgg cggcagcgga ggcagcggcg    180

gcagcaggag acgcagcggc ggccgcagca gcagcagcaa gacggactcg tggagacgcg    240

ccgccgccgc cgccgccggg ccgggccggg tgtcgcgcgc cgaggctggg ggggagtcgt    300

cgccgccgcc gccaccgcta ccgccgccgc cgccgccgcc gaggtgactg aggagagagg    360

cgcctcctcg ctcccgccac cgccggactt caatgcccag tccccagctc gccagcgttt    420

ttcgttggaa tatacgttgc acatttatgg cgattctgag tgtgagggca gacttctgcc    480

aggctcagca cagcattttc gctgacaagt gagcttggag gttctatgtg ccataattaa    540

cattgccttg aagactcctg gacaccgaga ctggcctcag aaatagttgg cttttttttt    600

tttttaattg caagcatatt tcttttaatg actccagtaa aattaagcat caagtaaaca    660

agtggaaagt gacctacact tttaacttgt ctcactagtg cctaaatgta gtaaaggctg    720

cttaagtttt gtatgtagtt ggattttttg gagtccgaat atttccatct gcagaaattg    780

aggcccaaat tgaatttgga ttcaagtgga ttctaaatac tttgcttatc ttgaagagag    840

aagcttcata aggaataaac aagttgaata gagaaaacac tgattgataa taggcatttt    900

agtggtcttt ttaatgtttt ctgctgtgaa acatttcaag atttattgat tttttttttt    960

cactttcccc atcacactca cacgcacgct cacacttttt atttgccata atgaaccgtc   1020

cagcccctgt ggagatctcc tatgagaaca tgcgttttct gataactcac aaccctacca   1080

atgctactct caacaagttc acagaggaac ttaagaagta tggagtgacg actttggttc   1140

gagtttgtga tgctacatat gataaagctc cagttgaaaa agaaggaatc cacgttctag   1200

attggccatt tgatgatgga gctccacccc ctaatcagat agtagatgat tggttaaacc   1260

tgttaaaaac caaatttcgt gaagagccag gttgctgtgt tgcagtgcat tgtgttgcag   1320

gattgggaag ggcacctgtg ctggttgcac ttgctttgat tgaatgtgga atgaagtacg   1380

aagatgcagt tcagtttata agacaaaaaa gaaggggagc gttcaattcc aaacagctgc   1440

tttatttgga gaaataccga cctaagatgc gattacgctt cagagatacc aatgggcatt   1500

gctgtgttca gtagaaggaa atgtaaacga aggctgactt gattgtgcca tttagaggga   1560

actcttggta cctggaaatg tgaatctgga atattacctg tgtcatcaaa gtagtgatgg   1620

attcagtact cctcaaccac tctcctaatg attggaacaa aagcaaacaa aaaagaaatc   1680

tctctataaa atgaataaaa tgtttaagaa aagagaaaga gaaaaggaat taattcagtg   1740

aaggatgatt ttgctcctag ttttggagtt tgaatttctg ccaggattga attattttga   1800

aatctcctgt ctttttaaac tttttcaaaa taggtctcta aggaaaacca gcagaacatt   1860

aggcctgtgc aaaaccatct gtttggggag cacactcttc cattatgctt ggcacataga   1920

tctccctgtg gtgggatttt ttttttccct ttttttgtgg gggagggttg gtggtatatt   1980

tttcccctct tttttccttc ctctcctaca tctccctttt cccccgatcc aagttgtaga   2040

tggaatagaa gcccttgttg ctgtagatgt gcgtgcagtc tggcagcctt aagcccacct   2100

gggcactttt agataaaaaa aaaaaaaaac aaaaaacaac accaaaaaaa cagcagtgat   2160

atatatattc caggtggttt ttagtcttta ctgatgaaag ggtgttcatg ttagtttctt   2220

caaaacccta tctaatacta ggcaaagtag ccaagagcct tttgttttgt ttttattttg   2280

ataaattagt ggagaaatgg cattttaaga ggagtctctt ctcaacttac ctgagagtcg   2340

aattcttctc ttccctaacc aatgaagcta agtggttatc ccagaaactt gtcttctaaa   2400

agggaggact ccaggccatc aataaagatg tccaggcagt gagcgtactt tttacaccct   2460

gtagaattgt gggctgtagc gttactctga ttttctgtct agtatcagag aatgctggta   2520

gcttaaaatt tttattttag gacttgtact ctgaattttc aggaaccgtc aaaggagcag   2580

cagcaaattc acatattttc gacttgagaa atgcttgtgg tatgtgtttt ccaaactgcc   2640

ccctatatgt aaagttcagt ttaaccactg attgccttgt tattactagg ttttttgaga   2700

ttaaaaaaaa aaaatccctg gtttaaaacc aacaatgatg cctagtgagt atgtgtccac   2760

aggccataac agggtagaag agagacatcg tgcaacccaa tgagtagtga agggactgtg   2820

ttgcttgtga agcggtgtag tagcattttt gcagattctt ggctgggttt agtgtactga   2880

tctagaaaag ctgtttttct gctcctttgt ggaaggcagt tatgatcagg ctgcatggac   2940

aaagcaggta gaggggcacc atcaggggct cttgcactat tttcacctct aaatattacg   3000

tactcagtag tgccctgctt ctagggctct gaatacgggc ttaaagtcat cttgtcctgc   3060

tggaatttgc tgtgcagagc cataagcctc ccattttgtt agcgtcagct aggccaatag   3120

gaacagaccg ggaccttgtc tcacactgat gatacctcac atgttgaccg gctatgtgaa   3180

ctgcctattt cctatgctgg agttttgatt tttaactaaa cgcaaatctg tagattctct   3240

cctctcccat cccagaaaac aaaacaaaat aatgcttttc gaaattgttt ctaggacttt   3300

aaaacataat ggtatatcca aaattcttta tttcagaatg caacaataga ttccattaat   3360

atagactcaa gatcaaaaca gcatacctgc taagctaaga tagatggtgt tgattccact   3420

gggttttgat caatacaata acaaaccttt ttcctttgac atactctgaa ttttgttgtt   3480

tggggggagg gggtgtgtgt gtgtgtgtgt gtgtgtgtgt gtattgtgtg tgtgtgtgtg   3540

tgcacgcgca gtgtccatca gtatcagtgc ctgcctgagt taggaaaatt acattcctgg   3600

ttctgtattg aggagaagga tgtataaagc aacatgaaac attagccctc cttttatttt   3660

aaagactaat gttaattgtt cttaaaactg gatttttttt ccttaaagca atttttttct   3720

tttcgattta atgaagtatt gctagctgaa gccagtttga catagagaga tgtcagattg   3780

atttgaaagg tgtgcagcct gatttaaaac caaaccctga acccttttaa agaacaataa   3840

aacatatttt acacgctcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa   3900

aaaaaaaaaa aaaaaaaaaa aaaaa                                         3925


<210>  2
<211>  504
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(504)

<400>  2
atg aac cgt cca gcc cct gtg gag atc tcc tat gag aac atg cgt ttt       48
Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asn Met Arg Phe         
1               5                   10                  15              

ctg ata act cac aac cct acc aat gct act ctc aac aag ttc aca gag       96
Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys Phe Thr Glu         
            20                  25                  30                  

gaa ctt aag aag tat gga gtg acg act ttg gtt cga gtt tgt gat gct      144
Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala         
        35                  40                  45                      

aca tat gat aaa gct cca gtt gaa aaa gaa gga atc cac gtt cta gat      192
Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp         
    50                  55                  60                          

tgg cca ttt gat gat gga gct cca ccc cct aat cag ata gta gat gat      240
Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp         
65                  70                  75                  80          

tgg tta aac ctg tta aaa acc aaa ttt cgt gaa gag cca ggt tgc tgt      288
Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys         
                85                  90                  95              

gtt gca gtg cat tgt gtt gca gga ttg gga agg gca cct gtg ctg gtt      336
Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val         
            100                 105                 110                 

gca ctt gct ttg att gaa tgt gga atg aag tac gaa gat gca gtt cag      384
Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln         
        115                 120                 125                     

ttt ata aga caa aaa aga agg gga gcg ttc aat tcc aaa cag ctg ctt      432
Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu         
    130                 135                 140                         

tat ttg gag aaa tac cga cct aag atg cga tta cgc ttc aga gat acc      480
Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe Arg Asp Thr         
145                 150                 155                 160         

aat ggg cat tgc tgt gtt cag tag                                      504
Asn Gly His Cys Cys Val Gln                                             
                165                                                     


<210>  3
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asn Arg Pro Ala Pro Val Glu Ile Ser Tyr Glu Asn Met Arg Phe 
1               5                   10                  15      


Leu Ile Thr His Asn Pro Thr Asn Ala Thr Leu Asn Lys Phe Thr Glu 
            20                  25                  30          


Glu Leu Lys Lys Tyr Gly Val Thr Thr Leu Val Arg Val Cys Asp Ala 
        35                  40                  45              


Thr Tyr Asp Lys Ala Pro Val Glu Lys Glu Gly Ile His Val Leu Asp 
    50                  55                  60                  


Trp Pro Phe Asp Asp Gly Ala Pro Pro Pro Asn Gln Ile Val Asp Asp 
65                  70                  75                  80  


Trp Leu Asn Leu Leu Lys Thr Lys Phe Arg Glu Glu Pro Gly Cys Cys 
                85                  90                  95      


Val Ala Val His Cys Val Ala Gly Leu Gly Arg Ala Pro Val Leu Val 
            100                 105                 110         


Ala Leu Ala Leu Ile Glu Cys Gly Met Lys Tyr Glu Asp Ala Val Gln 
        115                 120                 125             


Phe Ile Arg Gln Lys Arg Arg Gly Ala Phe Asn Ser Lys Gln Leu Leu 
    130                 135                 140                 


Tyr Leu Glu Lys Tyr Arg Pro Lys Met Arg Leu Arg Phe Arg Asp Thr 
145                 150                 155                 160 


Asn Gly His Cys Cys Val Gln 
                165         


<210>  4
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)

<400>  4
atg tcg cca tca caa ctc att ggg ttt ctg ctg ctc tgg gtt cca gcc       48
Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala         
1               5                   10                  15              

tcc agg ggt gaa att gtg ctg act cag agc cca gac tct ctg tct gtg       96
Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val         
            20                  25                  30                  

act cca ggc gag aga gtc acc atc acc tgc cgg gcc agt cag agc att      144
Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile         
        35                  40                  45                      

ggt agt agc tta cac tgg tac cag cag aaa cca ggt cag tct cca aag      192
Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys         
    50                  55                  60                          

ctt ctc atc aag tat gca tcc cag tcc ctc tca ggg gtc ccc tcg agg      240
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg         
65                  70                  75                  80          

ttc agt ggc agt gga tct ggg aca gat ttc acc ctc acc atc agt agc      288
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser         
                85                  90                  95              

ctc gag gct gaa gat gct gca gcg tat tac tgt cat cag agt agt cgt      336
Leu Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg         
            100                 105                 110                 

tta cct cac act ttc ggc caa ggg acc aag gtg gag atc aaa cgt acg      384
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr         
        115                 120                 125                     


<210>  5
<211>  128

<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val 
            20                  25                  30          


Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  6
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)

<400>  6
atg tcg cca tca caa ctc att ggg ttt ctg ctg ctc tgg gtt cca gcc       48
Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala         
1               5                   10                  15              

tcc agg ggt gaa att gtg ctg act cag agc cca gac tct ctg tct gtg       96
Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val         
            20                  25                  30                  

act cca ggc gag aga gtc acc atc acc tgc cgg gcc agt cag agc att      144
Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile         
        35                  40                  45                      

ggt agt agc tta cac tgg tac cag cag aaa cca ggt cag tct cca aag      192
Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys         
    50                  55                  60                          

ctt ctc atc aag tat gca tcc cag tcc ctc tca ggg gtc ccc tcg agg      240
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg         
65                  70                  75                  80          

ttc agt ggc agt gga tct ggg aca gat ttc acc ctc acc atc agt agc      288
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser         
                85                  90                  95              

ctc gag gct gaa gat ttc gca gtg tat tac tgt cat cag agt agt cgt      336
Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg         
            100                 105                 110                 

tta cct cac act ttc ggc caa ggg acc aag gtg gag atc aaa cgt acg      384
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr         
        115                 120                 125                     


<210>  7
<211>  128
<212>  PRT

<213>  Homo sapiens

<400>  7

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val 
            20                  25                  30          


Thr Pro Gly Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Val Pro Ser Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
                85                  90                  95      


Leu Glu Ala Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  8
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)

<400>  8
atg tcg cca tca caa ctc att ggg ttt ctg ctg ctc tgg gtt cca gcc       48
Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala         
1               5                   10                  15              

tcc agg ggt gaa att gtg ctg act cag agc cca ggt acc ctg tct gtg       96
Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val         
            20                  25                  30                  

tct cca ggc gag aga gcc acc ctc tcc tgc cgg gcc agt cag agc att      144
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile         
        35                  40                  45                      

ggt agt agc tta cac tgg tac cag cag aaa cca ggt cag gct cca agg      192
Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg         
    50                  55                  60                          

ctt ctc atc aag tat gca tcc cag tcc ctc tca ggg atc ccc gat agg      240
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg         
65                  70                  75                  80          

ttc agt ggc agt gga tct ggg aca gat ttc acc ctc acc atc agt aga      288
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg         
                85                  90                  95              

ctg gag cct gaa gat gct gca gcg tat tac tgt cat cag agt agt cgt      336
Leu Glu Pro Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg         
            100                 105                 110                 

tta cct cac act ttc ggc caa ggg acc aag gtg gag atc aaa cgt aca      384
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr         
        115                 120                 125                     


<210>  9
<211>  128
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Glu Pro Glu Asp Ala Ala Ala Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  10
<211>  384
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(384)

<400>  10
atg tcg cca tca caa ctc att ggg ttt ctg ctg ctc tgg gtt cca gcc       48
Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala         
1               5                   10                  15              

tcc agg ggt gaa att gtg ctg act cag agc cca ggt acc ctg tct gtg       96
Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val         
            20                  25                  30                  

tct cca ggc gag aga gcc acc ctc tcc tgc cgg gcc agt cag agc att      144
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile         
        35                  40                  45                      

ggt agt agc tta cac tgg tac cag cag aaa cca ggt cag gct cca agg      192
Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg         
    50                  55                  60                          

ctt ctc atc aag tat gca tcc cag tcc ctc tca ggg atc ccc gat agg      240
Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg         
65                  70                  75                  80          

ttc agt ggc agt gga tct ggg aca gat ttc acc ctc acc atc agt aga      288
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg         
                85                  90                  95              

ctg gag cct gaa gat ttc gca gtg tat tac tgt cat cag agt agt cgt      336
Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg         
            100                 105                 110                 

tta cct cac act ttc ggc caa ggg acc aag gtg gag atc aaa cgt aca      384
Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr         
        115                 120                 125                     


<210>  11
<211>  128
<212>  PRT
<213>  Homo sapiens


<400>  11

Met Ser Pro Ser Gln Leu Ile Gly Phe Leu Leu Leu Trp Val Pro Ala 
1               5                   10                  15      


Ser Arg Gly Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Val 
            20                  25                  30          


Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile 
        35                  40                  45              


Gly Ser Ser Leu His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
    50                  55                  60                  


Leu Leu Ile Lys Tyr Ala Ser Gln Ser Leu Ser Gly Ile Pro Asp Arg 
65                  70                  75                  80  


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg 
                85                  90                  95      


Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Ser Ser Arg 
            100                 105                 110         


Leu Pro His Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 
        115                 120                 125             


<210>  12
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  12
atg gag ttt ggg ctg agc tgg gtt ttc ctt gtt gct ata tta aaa ggt       48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly         
1               5                   10                  15              

gtc cag tgt gag gtt cag ctg gtg cag tct ggg gga ggc ttg gta aag       96
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys         
            20                  25                  30                  

cct ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc      144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe         
        35                  40                  45                      

agt agc ttt gct atg cac tgg gtt cgc cag gct cca gga aaa ggt ctg      192
Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu         
    50                  55                  60                          

gag tgg ata tca gtt att gat act cgt ggt gcc aca tac tat gca gac      240
Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp         
65                  70                  75                  80          

tcc gtg aag ggc cga ttc acc atc tcc aga gac aat gcc aag aac tcc      288
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser         
                85                  90                  95              

ttg tat ctt caa atg aac agc ctg aga gcc gag gac act gct gtg tat      336
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr         
            100                 105                 110                 

tac tgt gca aga ctg ggg aac ttc tac tac ggt atg gac gtc tgg ggc      384
Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly         
        115                 120                 125                     

caa ggg acc acg gtc acc gtc tcc tca                                  411
Gln Gly Thr Thr Val Thr Val Ser Ser                                     
    130                 135                                             


<210>  13
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  14
<211>  411
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(411)

<400>  14
atg gag ttt ggg ctg agc tgg gtt ttc ctt gtt gct ata tta aaa ggt       48
Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly         
1               5                   10                  15              

gtc cag tgt gag gtt cag ctg gtg cag tct ggg gga ggc ttg gta cag       96
Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln         
            20                  25                  30                  

ccc ggg ggg tcc ctg aga ctc tcc tgt gca gcc tct gga ttc acc ttc      144
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe         
        35                  40                  45                      

agt agc ttt gct atg cac tgg gtt cgc cag gct cca gga aaa ggt ctg      192
Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu         
    50                  55                  60                          

gag tgg ata tca gtt att gat act cgt ggt gcc aca tac tat gca gac      240
Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp         
65                  70                  75                  80          

tcc gtg aag ggc cga ttc acc atc tcc aga gac aat gcc aag aac tcc      288
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser         
                85                  90                  95              

ttg tat ctt caa atg aac agc ctg aga gcc gag gac act gct gtg tat      336
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr         
            100                 105                 110                 

tac tgt gca aga ctg ggg aac ttc tac tac ggt atg gac gtc tgg ggc      384
Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly         
        115                 120                 125                     

caa ggg acc acg gtc acc gtc tcc tca                                  411
Gln Gly Thr Thr Val Thr Val Ser Ser                                     
    130                 135                                             


<210>  15
<211>  137
<212>  PRT
<213>  Homo sapiens


<400>  15

Met Glu Phe Gly Leu Ser Trp Val Phe Leu Val Ala Ile Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Ser Phe Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
    50                  55                  60                  


Glu Trp Ile Ser Val Ile Asp Thr Arg Gly Ala Thr Tyr Tyr Ala Asp 
65                  70                  75                  80  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
                85                  90                  95      


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
            100                 105                 110         


Tyr Cys Ala Arg Leu Gly Asn Phe Tyr Tyr Gly Met Asp Val Trp Gly 
        115                 120                 125             


Gln Gly Thr Thr Val Thr Val Ser Ser 
    130                 135         


<210>  16
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  biotinylated peptide substrate

<400>  16

Asp Glu Ser Gly Pro Gly Cys Met Ser Cys Lys Cys Val Leu Ser 
1               5                   10                  15  


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  17
gaaauaccga ccuaagaugu u                                               21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  18
caucuuaggu cgguauuucu u                                               21


<210>  19
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  19
cgacuuuggu ucgaguuugu u                                               21


<210>  20
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  siRNA

<400>  20
caaacucgaa ccaaagucgu u                                               21


<210>  21
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  21
cactgttatc ggccagatga ag                                              22


<210>  22
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  22
gggccggttc tgttatatgt aga                                             23


<210>  23
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  23
aaggattgcc atatgtggag ccat                                            24


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  24
gctcgtccct gatggataaa                                                 20


<210>  25
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  25
ccatacggaa caacgtgct                                                  19


<210>  26
<211>  8
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  26
cttctgcc                                                               8


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  27
gtccaggcag tgagcgtact t                                               21


<210>  28
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  28
aattttaagc taccagcatt ctctga                                          26


<210>  29
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  29
cgttactctg attttctgtc tag                                             23


<210>  30
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  30
ctgctggtgc tggtctgtgt                                                 20


<210>  31
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  31
atgtccagct gcccgtagtt                                                 20


<210>  32
<211>  16
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  32
cattgccttg gctgtc                                                     16


<210>  33
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  33
aatccaacag caagggagat ttt                                             23


<210>  34
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  34
agcgtcagct gccagctaac                                                 20


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  35
tcataaggtg ctatctgttc a                                               21


<210>  36
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  36
ccgatgtgga ggtggagttc                                                 20


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer

<400>  37
tcccagtcct ctgtggatca                                                 20

<210>  38
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  probe

<400>  38
cctgtgacga tccaaga                                                    17


<210>  39
<211>  3445
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (221)..(856)

<400>  39
gagcaaccgc agcttctagt atccagactc cagcgccgcc ccgggcgcgg accccaaccc     60

cgacccagag cttctccagc ggcggcgcag cgagcagggc tccccgcctt aacttcctcc    120

gcggggccca gccaccttcg ggagtccggg ttgcccacct gcaaactctc cgccttctgc    180

acctgccacc cctgagccag cgcgggcgcc cgagcgagtc atg gcc aac gcg ggg      235
                                            Met Ala Asn Ala Gly         
                                            1               5           

ctg cag ctg ttg ggc ttc att ctc gcc ttc ctg gga tgg atc ggc gcc      283
Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu Gly Trp Ile Gly Ala         
                10                  15                  20              

atc gtc agc act gcc ctg ccc cag tgg agg att tac tcc tat gcc ggc      331
Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile Tyr Ser Tyr Ala Gly         
            25                  30                  35                  

gac aac atc gtg acc gcc cag gcc atg tac gag ggg ctg tgg atg tcc      379
Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu Gly Leu Trp Met Ser         
        40                  45                  50                      

tgc gtg tcg cag agc acc ggg cag atc cag tgc aaa gtc ttt gac tcc      427
Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys Lys Val Phe Asp Ser         
    55                  60                  65                          

ttg ctg aat ctg agc agc aca ttg caa gca acc cgt gcc ttg atg gtg      475
Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr Arg Ala Leu Met Val         
70                  75                  80                  85          

gtt ggc atc ctc ctg gga gtg ata gca atc ttt gtg gcc acc gtt ggc      523
Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe Val Ala Thr Val Gly         
                90                  95                  100             

atg aag tgt atg aag tgc ttg gaa gac gat gag gtg cag aag atg agg      571
Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu Val Gln Lys Met Arg         
            105                 110                 115                 

atg gct gtc att ggg ggt gcg ata ttt ctt ctt gca ggt ctg gct att      619
Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu Ala Gly Leu Ala Ile         
        120                 125                 130                     

tta gtt gcc aca gca tgg tat ggc aat aga atc gtt caa gaa ttc tat      667
Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile Val Gln Glu Phe Tyr         
    135                 140                 145                         

gac cct atg acc cca gtc aat gcc agg tac gaa ttt ggt cag gct ctc      715
Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu Phe Gly Gln Ala Leu         
150                 155                 160                 165         

ttc act ggc tgg gct gct gct tct ctc tgc ctt ctg gga ggt gcc cta      763
Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu Leu Gly Gly Ala Leu         
                170                 175                 180             

ctt tgc tgt tcc tgt ccc cga aaa aca acc tct tac cca aca cca agg      811
Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser Tyr Pro Thr Pro Arg         
            185                 190                 195                 

ccc tat cca aaa cct gca cct tcc agc ggg aaa gac tac gtg tga          856
Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys Asp Tyr Val                 
        200                 205                 210                     

cacagaggca aaaggagaaa atcatgttga aacaaaccga aaatggacat tgagatacta    916

tcattaacat taggacctta gaattttggg tattgtaatc tgaagtatgg tattacaaaa    976

caaacaaaca aacaaaaaac ccatgtgtta aaatactcag tgctaaacat ggcttaatct   1036

tattttatct tctttcctca atataggagg gaagattttt ccatttgtat tactgcttcc   1096

cattgagtaa tcatactcaa ttgggggaag gggtgctcct taaatatata tagatatgta   1156

tatatacatg tttttctatt aaaaatagac agtaaaatac tattctcatt atgttgatac   1216

tagcatactt aaaatatctc taaaataggt aaatgtattt aattccatat tgatgaagat   1276

gtttattggt atattttctt tttcgtctat atatacatat gtaacagtca aatatcattt   1336

actcttcttc attagctttg ggtgcctttg ccacaagacc tagcctaatt taccaaggat   1396

gaattctttc aattcttcat gcgtgccctt ttcatatact tattttattt tttaccataa   1456

tcttatagca cttgcatcgt tattaagccc ttatttgttt tgtgtttcat tggtctctat   1516

ctcctgaatc taacacattt catagcctac attttagttt ctaaagccaa gaagaattta   1576

ttacaaatca gaactttgga ggcaaatctt tctgcatgac caaagtgata aattcctgtt   1636

gaccttccca cacaatccct gtactctgac ccatagcact cttgtttgct ttgaaaatat   1696

ttgtccaatt gagtagctgc atgctgttcc cccaggtgtt gtaacacaac tttattgatt   1756

gaatttttaa gctacttatt catagtttta tatcccccta aactaccttt ttgttcccca   1816

ttccttaatt gtattgtttt cccaagtgta attatcatgc gttttatatc ttcctaataa   1876

ggtgtggtct gtttgtctga acaaagtgct agactttctg gagtgataat ctggtgacaa   1936

atattctctc tgtagctgta agcaagtcac ttaatctttc tacctctttt ttctatctgc   1996

caaattgaga taatgatact taaccagtta gaagaggtag tgtgaatatt aattagttta   2056

tattactctc attctttgaa catgaactat gcctatgtag tgtctttatt tgctcagctg   2116

gctgagacac tgaagaagtc actgaacaaa acctacacac gtaccttcat gtgattcact   2176

gccttcctct ctctaccagt ctatttccac tgaacaaaac ctacacacat accttcatgt   2236

ggttcagtgc cttcctctct ctaccagtct atttccactg aacaaaacct acgcacatac   2296

cttcatgtgg ctcagtgcct tcctctctct accagtctat ttccattctt tcagctgtgt   2356

ctgacatgtt tgtgctctgt tccattttaa caactgctct tacttttcca gtctgtacag   2416

aatgctattt cacttgagca agatgatgta atggaaaggg tgttggcatt ggtgtctgga   2476

gacctggatt tgagtcttgg tgctatcaat caccgtctgt gtttgagcaa ggcatttggc   2536

tgctgtaagc ttattgcttc atctgtaagc ggtggtttgt aattcctgat cttcccacct   2596

cacagtgatg ttgtggggat ccagtgagat agaatacatg taagtgtggt tttgtaattt   2656

aaaaagtgct atactaaggg aaagaattga ggaattaact gcatacgttt tggtgttgct   2716

tttcaaatgt ttgaaaacaa aaaaaatgtt aagaaatggg tttcttgcct taaccagtct   2776

ctcaagtgat gagacagtga agtaaaattg agtgcactaa acaaataaga ttctgaggaa   2836

gtcttatctt ctgcagtgag tatggcccga tgctttctgt ggctaaacag atgtaatggg   2896

aagaaataaa agcctacgtg ttggtaaatc caacagcaag ggagattttt gaatcataat   2956

aactcataag gtgctatctg ttcagtgatg ccctcagagc tcttgctgtt agctggcagc   3016

tgacgctgct aggatagtta gtttggaaat ggtacttcat aataaactac acaaggaaag   3076

tcagccactg tgtcttatga ggaattggac ctaataaatt ttagtgtgcc ttccaaacct   3136

gagaatatat gcttttggaa gttaaaattt aaatggcttt tgccacatac atagatcttc   3196

atgatgtgtg agtgtaattc catgtggata tcagttacca aacattacaa aaaaatttta   3256

tggcccaaaa tgaccaacga aattgttaca atagaattta tccaattttg atctttttat   3316

attcttctac cacacctgga aacagaccaa tagacatttt ggggttttat aataggaatt   3376

tgtataaagc attactcttt ttcaataaat tgttttttaa tttaaaaaaa ggaaaaaaaa   3436

aaaaaaaaa                                                           3445


<210>  40
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Ala Asn Ala Gly Leu Gln Leu Leu Gly Phe Ile Leu Ala Phe Leu 
1               5                   10                  15      


Gly Trp Ile Gly Ala Ile Val Ser Thr Ala Leu Pro Gln Trp Arg Ile 
            20                  25                  30          


Tyr Ser Tyr Ala Gly Asp Asn Ile Val Thr Ala Gln Ala Met Tyr Glu 
        35                  40                  45              


Gly Leu Trp Met Ser Cys Val Ser Gln Ser Thr Gly Gln Ile Gln Cys 
    50                  55                  60                  


Lys Val Phe Asp Ser Leu Leu Asn Leu Ser Ser Thr Leu Gln Ala Thr 
65                  70                  75                  80  


Arg Ala Leu Met Val Val Gly Ile Leu Leu Gly Val Ile Ala Ile Phe 
                85                  90                  95      


Val Ala Thr Val Gly Met Lys Cys Met Lys Cys Leu Glu Asp Asp Glu 
            100                 105                 110         


Val Gln Lys Met Arg Met Ala Val Ile Gly Gly Ala Ile Phe Leu Leu 
        115                 120                 125             


Ala Gly Leu Ala Ile Leu Val Ala Thr Ala Trp Tyr Gly Asn Arg Ile 
    130                 135                 140                 


Val Gln Glu Phe Tyr Asp Pro Met Thr Pro Val Asn Ala Arg Tyr Glu 
145                 150                 155                 160 


Phe Gly Gln Ala Leu Phe Thr Gly Trp Ala Ala Ala Ser Leu Cys Leu 
                165                 170                 175     


Leu Gly Gly Ala Leu Leu Cys Cys Ser Cys Pro Arg Lys Thr Thr Ser 
            180                 185                 190         


Tyr Pro Thr Pro Arg Pro Tyr Pro Lys Pro Ala Pro Ser Ser Gly Lys 
        195                 200                 205             


Asp Tyr Val 
    210     


<210>  41
<211>  1257
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (104)..(1093)

<400>  41
gtcccgacgc ctcccgcccc cgcagttcct tggagagctt ggagccgcgc gccggaggga     60

ataggaaagc ttggttacaa cccgggacac ccggagcttc agg atg gtt cgt act      115
                                                Met Val Arg Thr         
                                                1                       

aag aca tgg acc ctg aag aag cac ttt gtt ggc tat cct act aat agt      163
Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr Pro Thr Asn Ser         
5                   10                  15                  20          

gac ttt gag ttg aag aca tct gag ctc cca ccc tta aaa aat gga gag      211
Asp Phe Glu Leu Lys Thr Ser Glu Leu Pro Pro Leu Lys Asn Gly Glu         
                25                  30                  35              

gtc ctg ctt gaa gct ttg ttc ctc acc gtg gat ccc tac atg aga gtg      259
Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro Tyr Met Arg Val         
            40                  45                  50                  

gca gcc aaa aga ttg aag gaa ggt gat aca atg atg ggg cag caa gtg      307
Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met Gly Gln Gln Val         
        55                  60                  65                      

gcc aaa gtt gtg gaa agt aaa aat gta gcc cta cca aaa gga act att      355
Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro Lys Gly Thr Ile         
    70                  75                  80                          

gta ctg gct tct cca ggc tgg aca acg cac tcc att tct gat ggg aaa      403
Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile Ser Asp Gly Lys         
85                  90                  95                  100         

gat ctg gaa aag ctg ctg aca gag tgg cca gac aca ata cca ctg tct      451
Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr Ile Pro Leu Ser         
                105                 110                 115             

ttg gct ctg ggg aca gtt ggc atg cca ggc ctg act gcc tac ttt ggc      499
Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr Ala Tyr Phe Gly         
            120                 125                 130                 

cta ctt gaa atc tgt ggt gtg aag ggt gga gaa aca gtg atg gtt aat      547
Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr Val Met Val Asn         
        135                 140                 145                     

gca gca gct gga gct gtg ggc tca gtc gtg ggg cag att gca aag ctc      595
Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln Ile Ala Lys Leu         
    150                 155                 160                         

aag ggc tgc aaa gtt gtt gga gca gta ggg tct gat gaa aag gtt gcc      643
Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp Glu Lys Val Ala         
165                 170                 175                 180         

tac ctt caa aag ctt gga ttt gat gtc gtc ttt aac tac aag acg gta      691
Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn Tyr Lys Thr Val         
                185                 190                 195             

gag tct ttg gaa gaa acc ttg aag aaa gcg tct cct gat ggt tat gat      739
Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro Asp Gly Tyr Asp         
            200                 205                 210                 

tgt tat ttt gat aat gta ggt gga gag ttt tca aac act gtt atc ggc      787
Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn Thr Val Ile Gly         
        215                 220                 225                     

cag atg aag aaa ttt gga agg att gcc ata tgt gga gcc atc tct aca      835
Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly Ala Ile Ser Thr         
    230                 235                 240                         

tat aac aga acc ggc cca ctt ccc cca ggc cca ccc cca gag att gtt      883
Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro Pro Glu Ile Val         
245                 250                 255                 260         

atc tat cag gag ctt cgc atg gaa gct ttt gtc gtc tac cgc tgg caa      931
Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val Tyr Arg Trp Gln         
                265                 270                 275             

gga gat gcc cgc caa aaa gct ctg aag gac ttg ctg aaa tgg gtc tta      979
Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu Lys Trp Val Leu         
            280                 285                 290                 

gag ggt aaa atc cag tac aag gaa tat atc att gaa gga ttt gaa aac     1027
Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu Gly Phe Glu Asn         
        295                 300                 305                     

atg cca gcc gca ttt atg gga atg ctg aaa gga gat aat ttg ggg aag     1075
Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp Asn Leu Gly Lys         
    310                 315                 320                         

aca ata gtg aaa gca tga aaaagaggac acatggaatc tggaggccat            1123
Thr Ile Val Lys Ala                                                     
325                                                                     

ttagatgatt agttaatttg tttttcacca tttagcaaaa atgtatacta ccttaaatgt   1183

cttaagaaat agtactcata atgagtttga gctacttaat aaaatacatt taagtggtaa   1243

aaaaaaaaaa aaaa                                                     1257


<210>  42
<211>  329
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Val Arg Thr Lys Thr Trp Thr Leu Lys Lys His Phe Val Gly Tyr 
1               5                   10                  15      


Pro Thr Asn Ser Asp Phe Glu Leu Lys Thr Ser Glu Leu Pro Pro Leu 
            20                  25                  30          


Lys Asn Gly Glu Val Leu Leu Glu Ala Leu Phe Leu Thr Val Asp Pro 
        35                  40                  45              


Tyr Met Arg Val Ala Ala Lys Arg Leu Lys Glu Gly Asp Thr Met Met 
    50                  55                  60                  


Gly Gln Gln Val Ala Lys Val Val Glu Ser Lys Asn Val Ala Leu Pro 
65                  70                  75                  80  


Lys Gly Thr Ile Val Leu Ala Ser Pro Gly Trp Thr Thr His Ser Ile 
                85                  90                  95      


Ser Asp Gly Lys Asp Leu Glu Lys Leu Leu Thr Glu Trp Pro Asp Thr 
            100                 105                 110         


Ile Pro Leu Ser Leu Ala Leu Gly Thr Val Gly Met Pro Gly Leu Thr 
        115                 120                 125             


Ala Tyr Phe Gly Leu Leu Glu Ile Cys Gly Val Lys Gly Gly Glu Thr 
    130                 135                 140                 


Val Met Val Asn Ala Ala Ala Gly Ala Val Gly Ser Val Val Gly Gln 
145                 150                 155                 160 


Ile Ala Lys Leu Lys Gly Cys Lys Val Val Gly Ala Val Gly Ser Asp 
                165                 170                 175     


Glu Lys Val Ala Tyr Leu Gln Lys Leu Gly Phe Asp Val Val Phe Asn 
            180                 185                 190         


Tyr Lys Thr Val Glu Ser Leu Glu Glu Thr Leu Lys Lys Ala Ser Pro 
        195                 200                 205             


Asp Gly Tyr Asp Cys Tyr Phe Asp Asn Val Gly Gly Glu Phe Ser Asn 
    210                 215                 220                 


Thr Val Ile Gly Gln Met Lys Lys Phe Gly Arg Ile Ala Ile Cys Gly 
225                 230                 235                 240 


Ala Ile Ser Thr Tyr Asn Arg Thr Gly Pro Leu Pro Pro Gly Pro Pro 
                245                 250                 255     


Pro Glu Ile Val Ile Tyr Gln Glu Leu Arg Met Glu Ala Phe Val Val 
            260                 265                 270         


Tyr Arg Trp Gln Gly Asp Ala Arg Gln Lys Ala Leu Lys Asp Leu Leu 
        275                 280                 285             


Lys Trp Val Leu Glu Gly Lys Ile Gln Tyr Lys Glu Tyr Ile Ile Glu 
    290                 295                 300                 


Gly Phe Glu Asn Met Pro Ala Ala Phe Met Gly Met Leu Lys Gly Asp 
305                 310                 315                 320 


Asn Leu Gly Lys Thr Ile Val Lys Ala 
                325                 


<210>  43
<211>  1209
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(888)

<400>  43
acctctcaag cagccagcgc ctgcctgaat ctgttctgcc ccctccccac ccatttcacc     60

accacc atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc       108
       Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu          
       1               5                   10                           

ctc aca gtg ctt aca gtt gtt acg ggt tct ggt cat gca agc tct acc      156
Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr         
15                  20                  25                  30          

cca ggt gga gaa aag gag act tcg gct acc cag aga agt tca gtg ccc      204
Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro         
                35                  40                  45              

agc tct act gag aag aat gct ttg tct act ggg gtc tct ttc ttt ttc      252
Ser Ser Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe         
            50                  55                  60                  

ctg tct ttt cac att tca aac ctc cag ttt aat tcc tct ctg gaa gat      300
Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp         
        65                  70                  75                      

ccc agc acc gac tac tac caa gag ctg cag aga gac att tct gaa atg      348
Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met         
    80                  85                  90                          

ttt ttg cag att tat aaa caa ggg ggt ttt ctg ggc ctc tcc aat att      396
Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile         
95                  100                 105                 110         

aag ttc agg cca gga tct gtg gtg gta caa ttg act ctg gcc ttc cga      444
Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg         
                115                 120                 125             

gaa ggt acc atc aat gtc cac gac gtg gag aca cag ttc aat cag tat      492
Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr         
            130                 135                 140                 

aaa acg gaa gca gcc tct cga tat aac ctg acg atc tca gac gtc agc      540
Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser         
        145                 150                 155                     

gtg agt gat gtg cca ttt cct ttc tct gcc cag tct ggg gct ggg gtg      588
Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val         
    160                 165                 170                         

cca ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt ctg gtt gcg      636
Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala         
175                 180                 185                 190         

ctg gcc att gtc tat ctc att gcc ttg gct gtc tgt cag tgc cgc cga      684
Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg         
                195                 200                 205             

aag aac tac ggg cag ctg gac atc ttt cca gcc cgg gat acc tac cat      732
Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His         
            210                 215                 220                 

cct atg agc gag tac ccc acc tac cac acc cat ggg cgc tat gtg ccc      780
Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro         
        225                 230                 235                     

cct agc agt acc gat cgt agc ccc tat gag aag gtt tct gca ggt aat      828
Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn         
    240                 245                 250                         

ggt ggc agc agc ctc tct tac aca aac cca gca gtg gca gcc act tct      876
Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser         
255                 260                 265                 270         

gcc aac ttg tag gggcacgtcg cccgctgagc tgagtggcca gccagtgcca          928
Ala Asn Leu                                                             
                                                                        

ttccactcca ctcaggttct tcagggccag agcccctgca ccctgtttgg gctggtgagc    988

tgggagttca ggtgggctgc tcacagcctc cttcagaggc cccaccaatt tctcggacac   1048

ttctcagtgt gtggaagctc atgtgggccc ctgagggctc atgcctggga agtgttgtgg   1108

tgggggctcc caggaggact ggcccagaga gccctgagat agcggggatc ctgaactgga   1168

ctgaataaaa cgtggtctcc cactgcgcca aaaaaaaaaa a                       1209


<210>  44
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    

<210>  45
<211>  1334
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (204)..(842)

<400>  45
cgccgcgtgc gcctgcagac gctccgctcg ctgccttctc tcctggcagg cgctgccttt     60

tctccccgtt aaagggcact tgggctgaag gatcgctttg agatctgagg aacccgcagc    120

gctttgaggg acctgaagct gtttttcttc gttttccttt gggttcagtt tgaacgggag    180

gtttttgatc cctttttttc aga atg gat tat ttg ctc atg att ttc tct ctg    233
                          Met Asp Tyr Leu Leu Met Ile Phe Ser Leu       
                          1               5                   10        

ctg ttt gtg gct tgc caa gga gct cca gaa aca gca gtc tta ggc gct      281
Leu Phe Val Ala Cys Gln Gly Ala Pro Glu Thr Ala Val Leu Gly Ala         
                15                  20                  25              

gag ctc agc gcg gtg ggt gag aac ggc ggg gag aaa ccc act ccc agt      329
Glu Leu Ser Ala Val Gly Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser         
            30                  35                  40                  

cca ccc tgg cgg ctc cgc cgg tcc aag cgc tgc tcc tgc tcg tcc ctg      377
Pro Pro Trp Arg Leu Arg Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu         
        45                  50                  55                      

atg gat aaa gag tgt gtc tac ttc tgc cac ctg gac atc att tgg gtc      425
Met Asp Lys Glu Cys Val Tyr Phe Cys His Leu Asp Ile Ile Trp Val         
    60                  65                  70                          

aac act ccc gag cac gtt gtt ccg tat gga ctt gga agc cct agg tcc      473
Asn Thr Pro Glu His Val Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser         
75                  80                  85                  90          

aag aga gcc ttg gag aat tta ctt ccc aca aag gca aca gac cgt gag      521
Lys Arg Ala Leu Glu Asn Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu         
                95                  100                 105             

aat aga tgc caa tgt gct agc caa aaa gac aag aag tgc tgg aat ttt      569
Asn Arg Cys Gln Cys Ala Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe         
            110                 115                 120                 

tgc caa gca gga aaa gaa ctc agg gct gaa gac att atg gag aaa gac      617
Cys Gln Ala Gly Lys Glu Leu Arg Ala Glu Asp Ile Met Glu Lys Asp         
        125                 130                 135                     

tgg aat aat cat aag aaa gga aaa gac tgt tcc aag ctt ggg aaa aag      665
Trp Asn Asn His Lys Lys Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys         
    140                 145                 150                         

tgt att tat cag cag tta gtg aga gga aga aaa atc aga aga agt tca      713
Cys Ile Tyr Gln Gln Leu Val Arg Gly Arg Lys Ile Arg Arg Ser Ser         
155                 160                 165                 170         

gag gaa cac cta aga caa acc agg tcg gag acc atg aga aac agc gtc      761
Glu Glu His Leu Arg Gln Thr Arg Ser Glu Thr Met Arg Asn Ser Val         
                175                 180                 185             

aaa tca tct ttt cat gat ccc aag ctg aaa ggc aat ccc tcc aga gag      809
Lys Ser Ser Phe His Asp Pro Lys Leu Lys Gly Asn Pro Ser Arg Glu         
            190                 195                 200                 

cgt tat gtg acc cac aac cga gca cat tgg tga cagaccttcg gggcctgtct    862
Arg Tyr Val Thr His Asn Arg Ala His Trp                                 
        205                 210                                         

gaagccatag cctccacgga gagccctgtg gccgactctg cactctccac cctggctggg    922

atcagagcag gagcatcctc tgctggttcc tgactggcaa aggaccagcg tcctcgttca    982

aaacattcca agaaaggtta aggagttccc ccaaccatct tcactggctt ccatcagtgg   1042

taactgcttt ggtctcttct ttcatctggg gatgacaatg gacctctcag cagaaacaca   1102

cagtcacatt cgaattcggg tggcatcctc cggagagaga gagaggaagg agattccaca   1162

caggggtgga gtttctgacg aaggtcctaa gggagtgttt gtgtctgact caggcgcctg   1222

gcacatttca gggagaaact ccaaagtcca cacaaagatt ttctaaggaa tgcacaaatt   1282

gaaaacacac tcaaaagaca aacatgcaag taaagaaaaa aaaaaaaaaa aa           1334


<210>  46
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Asp Tyr Leu Leu Met Ile Phe Ser Leu Leu Phe Val Ala Cys Gln 
1               5                   10                  15      


Gly Ala Pro Glu Thr Ala Val Leu Gly Ala Glu Leu Ser Ala Val Gly 
            20                  25                  30          


Glu Asn Gly Gly Glu Lys Pro Thr Pro Ser Pro Pro Trp Arg Leu Arg 
        35                  40                  45              


Arg Ser Lys Arg Cys Ser Cys Ser Ser Leu Met Asp Lys Glu Cys Val 
    50                  55                  60                  


Tyr Phe Cys His Leu Asp Ile Ile Trp Val Asn Thr Pro Glu His Val 
65                  70                  75                  80  


Val Pro Tyr Gly Leu Gly Ser Pro Arg Ser Lys Arg Ala Leu Glu Asn 
                85                  90                  95      


Leu Leu Pro Thr Lys Ala Thr Asp Arg Glu Asn Arg Cys Gln Cys Ala 
            100                 105                 110         


Ser Gln Lys Asp Lys Lys Cys Trp Asn Phe Cys Gln Ala Gly Lys Glu 
        115                 120                 125             


Leu Arg Ala Glu Asp Ile Met Glu Lys Asp Trp Asn Asn His Lys Lys 
    130                 135                 140                 


Gly Lys Asp Cys Ser Lys Leu Gly Lys Lys Cys Ile Tyr Gln Gln Leu 
145                 150                 155                 160 


Val Arg Gly Arg Lys Ile Arg Arg Ser Ser Glu Glu His Leu Arg Gln 
                165                 170                 175     


Thr Arg Ser Glu Thr Met Arg Asn Ser Val Lys Ser Ser Phe His Asp 
            180                 185                 190         


Pro Lys Leu Lys Gly Asn Pro Ser Arg Glu Arg Tyr Val Thr His Asn 
        195                 200                 205             


Arg Ala His Trp 
    210         


<210>  47
<211>  1502
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (62)..(1189)

<400>  47
cctgcgtccc cgccccgcgc agccgccgcg ctcctgcgct ccgaggtccg aggttcccga     60

g atg aag gtc tgg ctg ctg ctt ggt ctt ctg ctg gtg cac gaa gcg ctg    109
  Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu       
  1               5                   10                  15            

gag gat gtt act ggc caa cac ctt ccc aag aac aag cgt cca aaa gaa      157
Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu         
            20                  25                  30                  

cca gga gag aat aga atc aaa cct acc aac aag aag gtg aag ccc aaa      205
Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys         
        35                  40                  45                      

att cct aaa atg aag gac agg gac tca gcc aat tca gca cca aag acg      253
Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr         
    50                  55                  60                          

cag tct atc atg atg caa gtg ctg gat aaa ggt cgc ttc cag aaa ccc      301
Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro         
65                  70                  75                  80          

gcc gct acc ctg agt ctg ctg gcg ggg caa act gta gag ctt cga tgt      349
Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys         
                85                  90                  95              

aaa ggg agt aga att ggg tgg agc tac cct gcg tat ctg gac acc ttt      397
Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe         
            100                 105                 110                 

aag gat tct cgc ctc agc gtc aag cag aat gag cgc tac ggc cag ttg      445
Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu         
        115                 120                 125                     

act ctg gtc aac tcc acc tcg gca gac aca ggt gaa ttc agc tgc tgg      493
Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp         
    130                 135                 140                         

gtg cag ctc tgc agc ggc tac atc tgc agg aag gac gag gcc aaa acg      541
Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr         
145                 150                 155                 160         

ggc tcc acc tac atc ttt ttt aca gag aaa gga gaa ctc ttt gta cct      589
Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro         
                165                 170                 175             

tct ccc agc tac ttc gat gtt gtc tac ttg aac ccg gac aga cag gct      637
Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala         
            180                 185                 190                 

gtg gtt cct tgt cgg gtg acc gtg ctg tcg gcc aaa gtc acg ctc cac      685
Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His         
        195                 200                 205                     

agg gaa ttc cca gcc aag gag atc cca gcc aat gga acg gac att gtt      733
Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val         
    210                 215                 220                         

tat gac atg aag cgg ggc ttt gtg tat ctg caa cct cat tcc gag cac      781
Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His         
225                 230                 235                 240         

cag ggt gtg gtt tac tgc agg gcg gag gcc ggg ggc aga tct cag atc      829
Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile         
                245                 250                 255             

tcc gtc aag tac cag ctg ctc tac gtg gcg gtt ccc agt ggc cct ccc      877
Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro         
            260                 265                 270                 

tca aca acc atc ttg gct tct tca aac aaa gtg aaa agt ggg gac gac      925
Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp         
        275                 280                 285                     

atc agt gtg ctc tgc act gtc ctg ggg gag ccc gat gtg gag gtg gag      973
Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu         
    290                 295                 300                         

ttc acc tgg atc ttc cca ggg cag aag gat gaa agg cct gtg acg atc     1021
Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile         
305                 310                 315                 320         

caa gac act tgg agg ttg atc cac aga gga ctg gga cac acc acg aga     1069
Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg         
                325                 330                 335             

atc tcc cag agt gtc att aca gtg gaa gac ttc gag acg att gat gca     1117
Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala         
            340                 345                 350                 

gga tat tac att tgc act gct cag aat ctt caa gga cag acc aca gta     1165
Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val         
        355                 360                 365                     

gct acc act gtt gag ttt tcc tga cttggaaaag gaaatgtaat gaacttatgg    1219
Ala Thr Thr Val Glu Phe Ser                                             
    370                 375                                             

aaagcccatt tgtgtacaca gtcagctttg gggttccttt tattagtgct ttgccagagg   1279

ctgatgtcaa gcaccacacc ccaaccccag cgtctcgtga gtccgaccca gacatccaaa   1339

ctaaaaggaa gtcatccagt ctattcacag aagtgttaac ttttctaaca gaaagcatga   1399

ttttgattgc ttacctacat acgtgttcct agtttttata catgtgtaaa caattttata   1459

taatcaatca tttctattaa atgagcacgt ttttgtaaaa aat                     1502


<210>  48
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Lys Val Trp Leu Leu Leu Gly Leu Leu Leu Val His Glu Ala Leu 
1               5                   10                  15      


Glu Asp Val Thr Gly Gln His Leu Pro Lys Asn Lys Arg Pro Lys Glu 
            20                  25                  30          


Pro Gly Glu Asn Arg Ile Lys Pro Thr Asn Lys Lys Val Lys Pro Lys 
        35                  40                  45              


Ile Pro Lys Met Lys Asp Arg Asp Ser Ala Asn Ser Ala Pro Lys Thr 
    50                  55                  60                  


Gln Ser Ile Met Met Gln Val Leu Asp Lys Gly Arg Phe Gln Lys Pro 
65                  70                  75                  80  


Ala Ala Thr Leu Ser Leu Leu Ala Gly Gln Thr Val Glu Leu Arg Cys 
                85                  90                  95      


Lys Gly Ser Arg Ile Gly Trp Ser Tyr Pro Ala Tyr Leu Asp Thr Phe 
            100                 105                 110         


Lys Asp Ser Arg Leu Ser Val Lys Gln Asn Glu Arg Tyr Gly Gln Leu 
        115                 120                 125             


Thr Leu Val Asn Ser Thr Ser Ala Asp Thr Gly Glu Phe Ser Cys Trp 
    130                 135                 140                 


Val Gln Leu Cys Ser Gly Tyr Ile Cys Arg Lys Asp Glu Ala Lys Thr 
145                 150                 155                 160 


Gly Ser Thr Tyr Ile Phe Phe Thr Glu Lys Gly Glu Leu Phe Val Pro 
                165                 170                 175     


Ser Pro Ser Tyr Phe Asp Val Val Tyr Leu Asn Pro Asp Arg Gln Ala 
            180                 185                 190         


Val Val Pro Cys Arg Val Thr Val Leu Ser Ala Lys Val Thr Leu His 
        195                 200                 205             


Arg Glu Phe Pro Ala Lys Glu Ile Pro Ala Asn Gly Thr Asp Ile Val 
    210                 215                 220                 


Tyr Asp Met Lys Arg Gly Phe Val Tyr Leu Gln Pro His Ser Glu His 
225                 230                 235                 240 


Gln Gly Val Val Tyr Cys Arg Ala Glu Ala Gly Gly Arg Ser Gln Ile 
                245                 250                 255     


Ser Val Lys Tyr Gln Leu Leu Tyr Val Ala Val Pro Ser Gly Pro Pro 
            260                 265                 270         


Ser Thr Thr Ile Leu Ala Ser Ser Asn Lys Val Lys Ser Gly Asp Asp 
        275                 280                 285             


Ile Ser Val Leu Cys Thr Val Leu Gly Glu Pro Asp Val Glu Val Glu 
    290                 295                 300                 


Phe Thr Trp Ile Phe Pro Gly Gln Lys Asp Glu Arg Pro Val Thr Ile 
305                 310                 315                 320 


Gln Asp Thr Trp Arg Leu Ile His Arg Gly Leu Gly His Thr Thr Arg 
                325                 330                 335     


Ile Ser Gln Ser Val Ile Thr Val Glu Asp Phe Glu Thr Ile Asp Ala 
            340                 345                 350         


Gly Tyr Tyr Ile Cys Thr Ala Gln Asn Leu Gln Gly Gln Thr Thr Val 
        355                 360                 365             


Ala Thr Thr Val Glu Phe Ser 
    370                 375


